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AssigneeThe University of Tokyo
InventorsYukihide Tomari, Shintaro Iwasaki, Kotaro Tsuboyama, Masaaki Oyama, Hiroko Hata, Hiro-oki Iwakawa, Eriko Matsuura
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Provided herein is a novel screening method for a client protein-protecting protein, and a physiologically active protein-stabilizing protein and a pharmaceutical composition using the protein. Also provided herein is a method for screening for a client protein-protecting protein, including the step of evaluating stability of a client protein in the presence of a protein having an intrinsically disordered structure. Also provided herein is an agent for stabilizing a physiologically active protein comprising, as an active ingredient, a protein having any one of amino acid sequences of SEQ ID NOs: 1 to 6; and a pharmaceutical composition including the protein and a physiologically active protein.
A method for screening for a client protein-protecting protein, comprising a step of selecting one or more candidate proteins having an intrinsically disordered structure from a protein population, optionally of mammalian origin, and a subsequent step of evaluating stability of a client protein in the presence of the one or more candidate proteins having the intrinsically disordered structure, and a step of determining that the candidate protein is a client-protein protecting protein when a degree of stability of the client protein in the presence of the candidate protein is above the degree of stability in the absence of the candidate protein or the degree of stability in the presence of a control protein.
Dependencies are inferred from the claim text.