Arrays of integrated analytical devices with reduced-scale unit cell
AssigneePacific Biosciences of California, Inc.
InventorsHans Callebaut, Mark McDonald, Arghavan Arjmand, Annette Grot, Mathieu Foquet, Ravi Saxena, Michael Tzu Ru
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Abstract
Arrays of integrated analytical devices are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. In particular, the arrays provide increased efficiency of optical collection and decreased background signal as the lateral dimensions of the unit cell of devices within the array are decreased, for example as they are decreased to 2 μm, or even less.
Claims37
An array of integrated analytical devices, each device comprising:
- a nanoscale emission volume;
- an excitation source optically coupled to the nanoscale emission volume;
- a detector layer optically coupled to the nanoscale emission volume;
- an upper light-directing element disposed between the nanoscale emission volume and the detector layer;
- and
- a lower light-directing element disposed between the upper light-directing element and the detector layer;
- wherein an optical signal is emitted from the nanoscale emission volume;
- and
- wherein the upper light-directing element and the lower light-directing element direct the optical signal from the nanoscale emission volume to a sensing region in the detector layer.
Dependencies are inferred from the claim text.