Methods for polymorphic screening
AssigneeUniversite de Montreal
InventorsAlexandre Levesque, Thierry Maris, James Wuest
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Abstract
A method for screening a target compound for polymorphic forms is provided. The method comprises providing a library of mixed-crystal seeds, each mixed-crystal seed consisting essentially of the target compound and at least one structural analog that is structurally analogous to the target compound; and for each mixed-crystal seed: introducing the mixed-crystal seed into a crystallization medium comprising the target compound, under conditions suitable for crystallization of the target compound; monitoring the formation of crystals of the target compound; and when formed, characterizing the crystals of the target compound.
Claims20
A method for screening a target compound for polymorphic forms, the method comprising:
- providing a library of mixed-crystal seeds, each mixed-crystal seed consisting essentially of the target compound and at least one structural analog that is structurally analogous to the target compound;
- and
- for each mixed-crystal seed:
- introducing the mixed-crystal seed into a crystallization medium comprising the target compound, under conditions suitable for crystallization of the target compound;
- monitoring the formation of crystals of the target compound;
- and
- when formed, characterizing the crystals of the target compound.
A method for crystallizing a target compound, the method comprising:
- providing a mixed-crystal seed consisting essentially of the target compound and at least one structural analog that is structurally analogous to the target compound;
- and
- introducing the mixed crystal seed into a crystallization medium comprising the target compound, to obtain crystals of the target compound.
Dependencies are inferred from the claim text.