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US 12,534,762 B2Granted
Treating atopic dermatitis by targeting the WNT pathway
AssigneeChildren's Medical Center Corporation
InventorsXi He, Maorong Chen
Life of this patent
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Abstract
Methods of treating subjects with atopic dermatitis, e.g., associated with mutations in the TMEM79 gene, using Wnt inhibitors, e.g., porcupine inhibitors.
Claims16
A method of treating a subject who has atopic dermatitis (AD), the method comprising administering a therapeutically effective amount of a porcupine (PORCN) inhibitor to a subject in need thereof, wherein the porcupine (PORCN) inhibitor is selected from the group consisting of LGK974;
- C59;
- ETC-159;
- ETC-131;
- and IWP compounds.
1 more element
A method of treating a subject who has atopic dermatitis (AD), the method comprising:
- obtaining a sample comprising genomic DNA from the subject;
- performing an assay to determine presence or absence of a mutation in TMEM79 in the genomic DNA from the subject;
- and
- administering a therapeutically effective amount of a porcupine (PORCN) inhibitor to a subject who has a mutation in TMEM79 that is associated with AD, wherein the porcupine (PORCN) inhibitor is selected from the group consisting of LGK974;
- C59;
- ETC-159;
- ETC-131;
- and IWP compounds.
5 more elements
A method of treating a subject who has atopic dermatitis (AD), the method comprising:
- obtaining a sample comprising affected skin cells from the subject;
- performing an assay to determine a level or activity of TMEM79 in the cells from the subject;
- detecting a reduction in level or activity of TMEM79 in the sample;
- and
- administering a therapeutically effective amount of a porcupine (PORCN) inhibitor to a subject who has a reduced level or activity of TMEM79 in the sample, wherein the porcupine (PORCN) inhibitor is selected from the group consisting of LGK974;
- C59;
- ETC-159;
- ETC-131;
- and IWP compounds.
6 more elements
Dependencies are inferred from the claim text.