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US 12,534,748 B2Granted
Engineered beta-subunit of tryptophan synthase for production of non-canonical amino acids
AssigneeCalifornia Institute of Technology
InventorsAndrew Richard Buller, Sabine Brinkmann-Chen, Michael Herger, David K. Romney, Javier Murciano Calles, Paul van Roye
Life of this patent
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Abstract
This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.
Claims12
A recombinant tryptophan synthase β-subunit (TrpB) mutant polypeptide comprising the sequence of any one of SEQ ID NOs:
- 10, 12, 14, 16, 18, or 20.
Dependencies are inferred from the claim text.