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US 12,534,713 B2Granted
Chimeric alkaline phosphatase-like proteins
AssigneeAM-Pharma B.V.
InventorsWillem Raaben, Luigi Johannes Cornelius Jonk, Erik Jan Van Den Berg, Andrea Van Elsas, José Luis Millán
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Abstract
The invention relates to improved alkaline phosphatases, pharmaceutical compositions comprising improved alkaline phosphatases and the use of improved alkaline phosphatases for preventing, treating or curing diseases.
Claims14
A method for improving, reducing or removing symptoms in a subject suffering from hypophosphatasia comprising administering to the subject:
- a protein having phosphatase activity, wherein said protein comprises an amino acid sequence of at least 200 consecutive amino acids having at least 90% sequence identity with SEQ ID NO:
- 5, an amino acid sequence of at least 50 consecutive amino acids, having at least 90% sequence identity with SEQ ID NO:
- 6, and an amino acid sequence of at least 40 consecutive amino acids having at least 90% sequence identity with SEQ ID NO:
- 7, wherein the full length protein comprises an amino acid sequence having at least 90% sequence identity with the full length amino acid sequence of SEQ ID NO:
- 1, with the proviso that the amino acid at position 279 is leucine (L), the amino acid at position 328 is valine (V) and the amino acid at position 478 is leucine (L).
2 more elements
A method for improving, reducing or removing symptoms in a subject suffering from hypophosphatasia, said method comprising administering to the subject:
- a composition comprising a protein having phosphatase activity, wherein said protein comprises an amino acid sequence of at least 200 consecutive amino acids having at least 90% sequence identity with SEQ ID NO:
- 5, an amino acid sequence of at least 50 consecutive amino acids, having at least 90% sequence identity with SEQ ID NO:
- 6, and an amino acid sequence of at least 40 consecutive amino acids having at least 90% sequence identity with SEQ ID NO:
- 7, wherein the full length protein comprises an amino acid sequence having at least 90% sequence identity with the full length amino acid sequence of SEQ ID NO:
- 1, with the proviso that the amino acid at position 279 is leucine (L), the amino acid at position 328 is valine (V) and the amino acid at position 478 is leucine (L).
2 more elements
Dependencies are inferred from the claim text.