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US 12,534,517 B2Granted
Highly specific zika neutralizing human antibodies
AssigneesUniversity of Vermont and State Agricultural College, The University of North Carolina at Chapel Hill
InventorsSean Diehl, Aravinda de Silva, Matthew Collins, Ben McElvany, Huy Tu
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Abstract
Provided herein, in some embodiments, are compositions of Zika-specific antibodies and antigen-binding fragments thereof and methods of using the antibodies and antigen-binding fragments.
Claims9
A method of treating a subject with Zika virus, comprising administering an effective amount of a composition to the subject, wherein the composition comprises:
- (a) an antibody or an antigen-binding antibody fragment that binds Domain I of Zika virus (ZIKV) Envelope protein (EDI), binds ZIKV strain MR766, or binds ZIKV Envelope protein III (EDIII), wherein the antibody or antigen-binding antibody fragment comprises a heavy chain variable region and a light chain variable region, and wherein:
- (i) the heavy chain variable region comprises an amino acid sequence that is identical to SEQ ID NO:
- 1 and the light chain variable region comprises an amino acid sequence that is identical to SEQ ID NO:
- 2;
- or
- (ii) the heavy chain variable region comprises an amino acid sequence that is identical to SEQ ID NO:
- 3 and the light chain variable region comprises an amino acid sequence that is identical to SEQ ID NO:
- 4;
- and
- (b) a pharmaceutically acceptable carrier.
7 more elements
Dependencies are inferred from the claim text.