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US 12,534,503 B2Granted
Mutant fibroblast growth factor 21 (FGF21) polypeptides
AssigneeYale University
InventorsJoseph Schlessinger, Sangwon Lee
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Abstract
Described herein soluble polypeptide comprising a FGF21 variant. The FGF21 variant comprises amino acid residues 29-209 of SEQ ID NO: 3, except that two or more amino acid residues in 29-209 of SEQ ID NO: 3 are mutated with respect to SEQ ID NO:3. The FGF21 variant comprises at least mutations L194F and R203W with respect to SEQ ID NO:3. Also described is a method of treating or ameliorating an endocrine FGF-related disease or disorder using the soluble polypeptide.
Claims6
A soluble polypeptide comprising a FGF21 variant,
- wherein the FGF21 variant is a variant of a polypeptide comprising amino acid residues 29-209 of SEQ ID NO:
- 3,
- wherein the FGF21 variant comprises mutations L194F and R203W relative to SEQ ID NO:
- 3, and
- wherein the FGF21 variant optionally further comprises one or more mutations selected from L126R, P199G, and A208E.
2 more elements
Dependencies are inferred from the claim text.