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US 12,534,487 B2Granted
Compounds for use as iron(III) MRI contrast agents
AssigneeThe Research Foundation for The State University of New York
InventorsJanet R. Morrow, Eric M. Snyder, Didar Asik
Life of this patent
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Abstract
Provided are macrocyclic compounds and compounds with two or more macrocyclic groups, iron coordinated macrocyclic compounds, and iron coordinated compounds with two or more macrocyclic groups. The iron is high-spin iron(III). The iron coordinated compounds may exhibit a negative redox potential (e.g., relative to a normal hydrogen electrode at a biologically relevant pH, for example, a pH of 6.5-7.5). The compounds can be used as MRI contrast agents.
Claims4
A macrocyclic core having the following structure:
- and Z1, Z2, and Z3 are each independently H or one or more of the following pendant groups:
- or a deprotonated analog thereof or a stereoisomer thereof, wherein R is methyl, and Ri is independently a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted alkyl group, and R1 is not pendant donors;
- Q4 and Q5 are each independently H, OCH3, CO2H, or substituted or unsubstituted alkyl groups of linear or branched structures, A is a substituted or unsubstituted alkyl group of linear or branched structure with C1 to C12 or is a substituted or unsubstituted aryl group or an amino acid, or a salt, a partial salt, a hydrate, a polymorph, or a stereoisomer thereof, wherein the macrocyclic core has structure II or III, Z1 and Z2 are each independently a pendant group;
- wherein for all structures I, II, and III, each of Z1, Z2, and Z3, as applicable, are selected independently of each other, and at least one of R, Z1, Z2, and Z3 is different than the remaining R, Z1, Z2, and Z3.
1 more element
A macrocyclic core having the following structure:
Dependencies are inferred from the claim text.