Continuous flow process for preparation of acephate and its intermediates

A process for production of acephate comprising converting O, S-dimethyl phosphoramidothioate into acephate, the process comprising:

• i) charging O, O-dimethyl phosphoramidothioate to a microreactor unit through a first line of the microreactor unit;
• ii) charging dimethyl sulphate to the microreactor unit through a second line of the microreactor unit;
• (iii) reacting O, O-dimethyl phosphoramidothioate and dimethyl sulphate in the microreactor unit to form a product stream of O, S-dimethyl phosphoramidothioate;
• and
• (iv) converting the O, S-dimethyl phosphoramidothioate into acephate
• wherein said O, S-dimethyl phosphoramidothioate is prepared continuously by reacting O, O-dimethyl phosphoramidothioate and dimethyl sulphate in the microreactor unit, and
• wherein the acephate is continuously prepared in an absence of solvent.