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US 12,534,440 B2Granted
Compounds with copper- or zinc-activated toxicity against microbial infection
AssigneesKansas State University Research Foundation, The UAB Research Foundation
InventorsStefan H. Bossmann, Madumali Kalubowilage, Man Zhang, Anjana Delpe-Acharige, Kayla Eschliman, Frank Wolschendorf, Olaf Kutsch, Alex Dalecki, Whitney Narmore
Life of this patent
Estimating the term…
Abstract
Heterocyclic compounds with a novel pyrazole thioamide-based NNSN structural motif, having highly effective zinc- or copper-activated toxicity against microbial infections at micromolar or nanomolar minimum inhibitory concentrations (MIC), and methods of making and using the same.
Claims26
A copper(I)- or zinc(II)-activated compound of formula I or formula II:
- or a pharmaceutically-acceptable salt thereof, where:
- R1 is a substituted aryl;
- and
- R2 is a branched or unbranched alkyl or alkenyl that may be substituted, or R2 is a substituted or unsubstituted amine, a substituted or unsubstituted amide, an ether, a thioether, an ester, a carboxylic acid, a substituted or unsubstituted aryl, a thiourea group, or a benzyloxy group;
- and
- R3 is hydrogen, a halogen, a branched or unbranched alkyl or alkenyl, a cycloalkyl, a heterocycle, an ether, a thioether, an ester, an amine, an amide, a hydrazine, a hydrazone, or a nitro group;
- and
- R4 is hydrogen, a halogen, a branched or unbranched alkyl or alkenyl, a cycloalkyl, a heterocycle, an ether, a thioether, an ester, an amine, an amide, a hydrazine, a hydrazone, or a nitro group;
- and
- R5 is hydrogen or a branched or unbranched alkyl or alkenyl that may be substituted.
7 more elements
Dependencies are inferred from the claim text.