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US 12,534,433 B2Granted
Antimicrobial compounds and nanostructures
AssigneeThe Boeing Company
InventorsMichael Monteiro, Jason W. Armstrong
Life of this patent
Estimating the term…
Abstract
The present disclosure provides compounds and nanostructures having one or more quaternary ammonium salts, compositions including the compounds and nanostructures, and methods useful for treating conditions using the compounds, nanostructures, and compositions. In at least one aspect, a compound is represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein: Q is fluoro, chloro, bromo, or iodo; each of s, b, and n is independently an integer from about 10 to about 100; and each of v, j, p, z, q, x and m is independently an integer from 1 to about 20.
Claims20
A method comprising:
- preparing a composition by mixing a first compound and a second compound,
- the first compound represented by Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- Q of Formula (I) is fluoro, chloro, bromo, or iodo;
- s of Formula (I) is an integer from 10 to 100;
- b of Formula (I) is an integer from 10 to 100;
- n of Formula (I) is an integer from 10 to 100;
- v of Formula (I) is an integer from 1 to 20;
- j of Formula (I) is an integer from 1 to 20;
- p of Formula (I) is an integer from 1 to 20;
- z of Formula (I) is an integer from 1 to 20;
- q of Formula (I) is an integer from 1 to 20;
- x of Formula (I) is an integer from 1 to 20;
- and
- m of Formula (I) is an integer from 1 to 20, and
- the second compound represented by formula (IV):
- or a pharmaceutically acceptable salt thereof, wherein:
- each of s and b of formula (IV) is independently an integer from 10 to 100;
- v of formula (IV) is an integer from 1 to 20;
- R1 of formula (IV) is —O— or —NH—;
- and
- R2 of formula (IV) is —CH3, biotin, pyridyl disulfide,
- thiolactonyl, or adamantyl.
20 more elements
A method comprising:
- preparing a nanoworm by mixing a first compound and a second compound, the first compound consisting of:
- a polystyrene block;
- a poly(N-isopropylacrylamide) block;
- ammonium moieties represented by the formula:
- wherein n is an integer of 10 to 100 and each z is independently an integer of from 1 to 20;
- ammonium moieties represented by the formula:
- wherein Q is selected from the group consisting of fluoro, chloro, bromo, and iodo, wherein each of m is an integer of 1 to 20 and each q and each x is independently an integer of 1 to 20;
- a moiety represented by the formula:
- wherein v is an integer of 1 to 20;
- and
- a moiety represented by the formula:
- wherein j and p are independently an integer of 1 to 20;
- or a pharmaceutically acceptable salt of the first compound, and
- the second compound consisting of:
- a second polystyrene block;
- a second poly(N-isopropylacrylamide) block;
- and
- a moiety represented by the formula:
- wherein v is an integer of 1 to 20;
- and
- a moiety represented by the formula:
- wherein R1 is selected from the group consisting of —O— and —NH—, and R2 is selected from the group consisting of —CH3, biotin, pyridyl disulfide,
- thiolactonyl, and adamantly, or a pharmaceutically acceptable salt of the second compound.
20 more elements
A method comprising:
- preparing a nanoworm by mixing a first compound and a second compound, the first compound consisting of:
- a polystyrene block;
- a poly(N-isopropylacrylamide) block;
- ammonium moieties represented by the formula:
- wherein n is an integer of 10 to 100 and each z is independently an integer of from 1 to 20;
- ammonium moieties represented by the formula:
- wherein Q is selected from the group consisting of fluoro, chloro, bromo, and iodo, wherein each of m is an integer of 1 to 20 and each q and each x is independently an integer of 1 to 20;
- a moiety represented by the formula:
- wherein v is an integer of 1 to 20;
- and
- a moiety represented by the formula:
- wherein j and p are independently an integer of 1 to 20;
- or a pharmaceutically acceptable salt of the first compound, and
- the second compound consisting of:
- a second polystyrene block;
- a second poly(N-isopropylacrylamide) block;
- and
- a moiety represented by the formula:
- wherein v is an integer of 1 to 20;
- and
- a moiety represented by the formula:
- wherein R1 is selected from the group consisting of —O— and —NH—, and R2 is selected from the group consisting of —CH3, biotin, pyridyl disulfide,
- thiolactonyl, and adamantly,
- or a pharmaceutically acceptable salt of the second compound;
- and
- forming a nanorod from the nanoworm.
23 more elements
Dependencies are inferred from the claim text.