Non-distillative process for manufacturing high purity amphetamines

A process, comprising:

• (i) reacting (S or R,S) (dialkyl or diaryl)(1-phenylpropan-2-yl)phosphoramidate, with 3N HCl at 80° C. for 1.5 h, cooling to room temperature, adding toluene and agitating, and removing an organic layer;
• (i reacting the organic layer with 50% NaOH to adjust pH to 13, agitating with methyl-tert-butyl-ether (MTBE), separating an aqueous layer from an organic layer, washing the organic layer with MTBE;
• (iii) diluting the organic layer with isopropanol, warming to 45-50° C., and concentrating under vacuum to obtain (S or R,S) (dialkyl or diaryl)(1-phenylpropan-2-yl)amine dissolved in isopropanol;
• (iv) adding H2SO4 aq and isopropanol to the (S or R,S) (dialkyl or diaryl) (1-phenylpropan-2-yl)-amine dissolved in isopropanol while maintaining 45-50° C.;
• (v) adding isopropanol, and warming to 80° C. for 1 h, cooling to 50° C. over 6 h, 20° C. over 5 h, and maintaining at 20° C. for 4 h;
• (vi) adding isopropanol and cooling to 5° C., agitating for 6 h;
• (vii) collecting a solid by filtration, washing with cold isopropanol/water;
• wherein the solid is a (S or R,S) (dialkyl or diaryl) (1-phenylpropan-2-yl)-amine [H2SO4] having a purity of >99.9%.

A process, comprising:

• (i) reacting (S or R,S) (dialkyl or diaryl)(1-phenylpropan-2-yl)phosphoramidate, with H2SO4 aq and warming to 80° C. for 1 h, cooling to 20° C.;
• (ii) adding toluene, concentrating under vacuum, wash/repeat until water wt. is 0.11 weight %;
• (iii) adding toluene, warming to 80° C., agitating 1 h, cooling to 50° C. over 2 h, cooling to RT, and holding at RT 4-24 h;
• (iv) cooling to 5° C., and holding for 12 h;
• (v) collecting a solid by filtration;
• wherein the solid is a (S or R,S) (dialkyl or diaryl) (1-phenylpropan-2-yl)-amine [H2SO4] having a purity of >99.92% AUC.