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US 12,533,418 B2Granted
Dosage and administration of a bacterial saccharide glycoconjugate vaccine
AssigneeGlaxosmithkline Biologicals SA
InventorsRoberto Adamo, Giuseppe Del Giudice, Sanjay Phogat
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Abstract
The present invention provides a glycoconjugate for administration to a subject in a method comprising the steps of: (i) administering a first dose of glycoconjugate; (ii) subsequently administering a second dose of glycoconjugate; wherein the amount of glycoconjugate in the first dose or first and second doses are atypically low, and also related aspects.
Claims8
A method of administering a glycoconjugate to a subject, the method comprising the steps of:
- (i) administering a first dose of 0.005 to 2 μg of glycoconjugate;
- (ii) subsequently administering a second dose of 1 to 30 μg of glycoconjugate, wherein the amount of glycoconjugate in the second dose is at least twice the amount of glycoconjugate in the first dose, wherein the glycoconjugate comprises a saccharide derived from Group B Streptococcus.
A kit comprising:
- (i) a first dose of glycoconjugate;
- (ii) a second dose of glycoconjugate;
- wherein the first dose is 0.005 to 2 μg of glycoconjugate;
- wherein the second dose is 1 to 30 μg of glycoconjugate, wherein the amount of glycoconjugate in the second dose is at least twice the amount of glycoconjugate in the first dose, wherein the glycoconjugate comprises a saccharide derived from Group B Streptococcus.
1 more element
Dependencies are inferred from the claim text.