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AssigneeSociete des Produits Nestle S.A.
InventorsGabriela Bergonzelli Degonda, Laurent Favre, Laurent Ferrier, Clara Lucia Garcia-Rodenas
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The present invention relates to compositions comprising a mix of human milk oligosaccharides consisting of 2′-fucosyllactose and difucosyllactose, for use in the reduction of pain and/or perception of pain in an infant or in a young child. The compositions are particularly effective in the restoration of the sensitivity of the bi-directional pain transmission pathways in the gut-brain axis to normal levels. The compositions are in particular useful in reducing abdominal pain, such as pain associated with gastrointestinal discomfort, functional gastrointestinal disorders, and/or gastrointestinal diseases and consequently also contribute to reducing the crying periods and to improving the quality of sleep, the general quality of life, the mood, the playfulness, the temperament and/or the happiness of the infants and young children.
A method for reducing pain and/or perception of pain in an infant under the age of 12 months or a young child aged between one and three years of age, the method comprising administering a nutritional composition comprising a mix of human milk oligosaccharides (HMOs) consisting of 2′-fucosyllactose (2′-FL) and difucosyllactose (DiFL) to the infant or young child, wherein the nutritional composition comprises the mix of HMOs in an amount effective to deliver a total daily dose of about 0.1 g to about 10 g of HMOs to the infant or young child upon normal daily consumption of the nutritional composition.
A method for reducing nociception in a child between three and seven years of age, the method comprising administering a growing-up milk comprising a mix of human milk oligosaccharides consisting of 2′-FL and DiFLto the child.
Dependencies are inferred from the claim text.