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US 12,533,343 B2Granted
Method for preparing (−)-cibenzoline succinate
AssigneeCelltrion Inc.
InventorsSrinivas Reddy Desi Reddy, Vijayavitthal Thippannachar Mathad, Dnyandev Ragho Rane, Vikas Shivaji Patil
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Abstract
The present invention relates to a crystal form of (−)-Cibenzoline succinate. In addition, the present invention relates to a method for preparing (−)-cibenzoline succinate having a chiral purity of 99.9% or higher. Additionally, the present invention provides a method for preparing (−)-cibenzoline succinate and a crystal form thereof.
Claims11
A crystalline form of (−)-Cibenzoline succinic acid salt of formula (IA)
- wherein the crystalline form has an X-ray powder diffraction (XRPD) pattern comprising diffraction peaks at 11.2°, 14.1°, 17.3°, 22.10, 23.0°, and 24.3° (2θ±0.2°).
A crystalline form of (−)-Cibenzoline succinic acid salt of formula (IA)
- wherein the crystalline form has an XRPD pattern comprising diffraction peaks at 8.99°, 11.15°, 13.36°, 14.09°, 14.30°, 17.29°, 17.59°, 18.15°, 19.81°, 21.37°, 22.06°, 22.93°, 24.25°, 25.41°, 26.36°, 27.59°, and 29.50° (2θ).
Dependencies are inferred from the claim text.