Polypeptide formulations for oral delivery
AssigneeBhami's Research Laboratory, Pvt. Ltd.
InventorsBhami Shenoy, Suryakanth Motilal Pai
Life of this patent
Estimating the term…
Abstract
The present disclosure provides, among other things, methods and compositions for the oral administration of polypeptides. Many polypeptides are typically administered in liquid solutions by intravenous or subcutaneous injection. The present disclosure provides methods and compositions that include a polypeptide formulation, e.g., truffle, tablet, globule, candy, capsule formulation suitable for oral administration, where the formulation includes an amorphous polypeptide composition or a crystallized polypeptide composition and a pharmaceutically acceptable carrier.
Claims31
A polypeptide formulation comprising a polypeptide component and a pharmaceutically acceptable carrier, wherein:
- the polypeptide component consists of distinct carrier and active polypeptides, each of which is an unmodified polypeptide or a polypeptide that is modified by one or more of acetylation, acylation, amidation, glycation, glycosylation, lipidation, mannosylation, methylation, nitrosylation, phosphorylation, sulfation, palmitoylation, pegylation, and prenylation, and further wherein:
- (a) the polypeptide component is in a solid form;
- (b) the active polypeptide is insulin;
- (c) one or both of the polypeptides is crystallized;
- and
- (d) the active polypeptide component is embedded in a crystalized carrier polypeptide component.
A polypeptide formulation comprising a polypeptide component and a pharmaceutically acceptable carrier, wherein:
- the polypeptide component consists of distinct carrier and active polypeptides, at least the carrier polypeptide is in crystalline form, and the active polypeptide is embedded within the crystallized carrier polypeptide.
Dependencies are inferred from the claim text.