Model-informed precision dosing systems for treatment of inflammatory bowel disease
AssigneeChildren's Hospital Medical Center
InventorsPhillip Minar, Alexander Vinks
Life of this patent
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Abstract
Disclosed are methods for preparing a patient-specific vedolizumab dosing regimen for an individual in need thereof, comprising accessing, using a processor, a memory; selecting a first model stored in the memory; forecasting, based on the selected first model, a patient-specific predicted concentration time profile of the vedolizumab, selecting a dosing regimen, based on said forecasting, wherein said dosing regimen achieves a treatment objective, said treatment objective being a therapeutic level of vedolizumab; and outputting said dosing regimen. Further disclosed are methods of treating an individual having an inflammatory bowel disease.
Claims20
A method for preparing a patient-specific vedolizumab dosing regimen for an individual diagnosed with an inflammatory bowel disease in need thereof, comprising
- a. accessing, using a processor, a memory;
- b. selecting a first model stored in the memory wherein the model comprises determining systemic clearance (CL) of vedolizumab based on the following:
- CL=CLpop×(WT/70)0.606×(ALB/3.5)−1.44×(ESR/9)0.112, wherein CLpop is the typical population CL for a patient, WT represents body weight, ALB represents albumin level, and ESR represents erythrocyte sedimentation rate;
- c. forecasting, based on the selected first model, a patient-specific predicted concentration-time profile of the vedolizumab,
- d. selecting a dosing regimen, based on the forecasting, wherein the dosing regimen achieves a treatment objective, said treatment objective being a therapeutic level of vedolizumab in the patient;
- e. outputting the dosing regimen;
- and
- f. administering the vedolizumab to the individual based on the dosing regimen.
A system for preparing a patient-specific vedolizumab dosing regimen for an individual diagnosed with an inflammatory bowel disease in need thereof, comprising computer-readable, processor-executable instruction for carrying out a method comprising
- a. accessing, using a processor, a memory;
- b. selecting a first model stored in the memory wherein the model comprises determining systemic clearance (CL) of vedolizumab based on the following:
- CL=CLpop×(WT/70)0.606×(ALB/3.5)−1.44×(ESR/9)0.112, wherein CLpop is the typical population CL for a patient, WT represents body weight, ALB represents albumin level, and ESR represents erythrocyte sedimentation rate;
- c. forecasting, based on the selected first model, a patient-specific predicted concentration-time profile of the vedolizumab,
- d. selecting a dosing regimen, based on the forecasting, wherein the dosing regimen achieves a therapeutic level of vedolizumab in the patient;
- and
- e. outputting the dosing regimen for administering the vedolizumab to the individual.
Dependencies are inferred from the claim text.