Anti-human-IL-1-βantibodies, encoding nucleic acids thereof and methods of using thereof to treat inflammatory diseases and cancer
AssigneeEli Lilly and Company
InventorsWendy Loza Hobbs, Andrew Dixon Skora
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Abstract
The present disclosure provides human engineered IL-1 beta antibodies, cells and vectors comprising DNA encoding the same, and methods for producing the antibodies. In addition, the present disclosure provides the use of the human engineered IL-1 beta antibodies for the treatment of inflammatory diseases such as cardiovascular disease and cancer.
Claims24
An antibody that binds human IL-1β protein comprising a heavy chain variable region (VH) and a light chain variable region (VL), wherein the VH comprises heavy chain complementarity determining regions (HCDR) HCDR1, HCDR2, and HCDR3, and the VL comprises light chain complementarity determining regions (LCDR) LCDR1, LCDR2, and LCDR3, wherein
- (SEQ ID NO:7)
- the HCDR1 comprises AASGFTFSDHYMS,
- (SEQ ID NO:8)
- the HCDR2 comprises YISSSGSTIYYADSVKG,
- (SEQ ID NO:9)
- the HCDR3 comprises AREADSSGYYYVGVDV,
- (SEQ ID NO:11)
- the LCDR1 comprises RASQSISSYLN,
- (SEQ ID NO:12)
- the LCDR2 comprises YGASSDQS, and
- (SEQ ID NO:13)
- the LCDR3 comprises QQGYYFPPT.
A nucleic acid comprising a sequence encoding SEQ ID NO:2 or 4.
A composition comprising
- (a) a vector comprising a first nucleic acid sequence encoding SEQ ID NO:2 and a second nucleic acid sequence encoding SEQ ID NO:4;
- or
- (b) a first vector comprising a nucleic acid sequence encoding SEQ ID NO:2 and a second vector comprising a nucleic acid sequence encoding SEQ ID NO:4.
A cell comprising
- (a) a vector comprising a first nucleic acid sequence encoding SEQ ID NO:2 and a second nucleic acid sequence encoding SEQ ID NO:4;
- or
- (b) a first vector comprising a nucleic acid sequence encoding SEQ ID NO:2 and a second vector comprising a nucleic acid sequence encoding SEQ ID NO:4.
Dependencies are inferred from the claim text.