T-cell receptor for treating fibrolamellar hepatocellular carcinoma
AssigneesSt. Jude Children's Research Hospital, University of Maryland, Baltimore
InventorsPaul Thomas, Jeremy Crawford, Allison Kirk, Anthony Zamora, Scott E. Strome
Life of this patent
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Abstract
A vector harboring nucleic acids encoding a recombinant T cell receptor having antigenic specificity for a DnaJ heat shock protein family member B1-protein kinase cAMP-activated catalytic subunit alpha (DNAJB1-PRKACA) fusion protein is provided, as are host cells and a method for treating fibrolamellar hepatocellular carcinoma with the vector.
Claims7
A vector harboring nucleic acids encoding a recombinant T cell receptor having antigenic specificity for a DnaJ heat shock protein family member B1-protein kinase CAMP-activated catalytic subunit alpha (DNAJB1-PRKACA) fusion protein, wherein the T cell receptor comprises
- (i) an α chain variable region comprising the amino acid sequence CALDMESGGYNKLIF (SEQ ID NO:3), CALSEAEDSGGSNYKLTF (SEQ ID NO:8), CAEGLLSGNTPLVE (SEQ ID NO:9), CAVNILGNKLVE (SEQ ID NO:10), CAVIMDSNYQLIW (SEQ ID NO:11), CASLGVTGGGNKLTF (SEQ ID NO:12), CAAHTGTASKLTF (SEQ ID NO:13), CAVSDDYGGSQGNLIF (SEQ ID NO:14), CAVSRRPGGGNTPLVF (SEQ ID NO:15), or CAVPGNNKFYF (SEQ ID NO:16);
- (ii) a β chain variable region comprising the amino acid sequence CATSRVKTSGGYEQYF (SEQ ID NO:4), CASSELGSTDTOYF (SEQ ID NO:17), CASSPGOGSRTEAFF (SEQ ID NO:18), CASSQEGGRLVGTQYF (SEQ ID NO:19), CASSLSLGGRGPDTQYF (SEQ ID NO:20), CASSQDGAGQGYTF (SEQ ID NO:21), CASNPLGGNQPQHF (SEQ ID NO:22), CASSQEVRMNTEAFF (SEQ ID NO:23), CSAKTTGEVPYEQYF (SEQ ID NO:24), or CASSANPTDPVILRYGYTF (SEQ ID NO:25);
- or (iii) both (i) and (ii).
Dependencies are inferred from the claim text.