Method of producing transduction particles
AssigneeSNIPR Biome ApS
InventorSzabolcs Semsey
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Abstract
The invention relates to the production of transduction particles, such as phage, as well as compositions comprising the particles and use of these. The particles are particularly useful for delivering toxic payloads into target bacteria for antibacterial action. The invention is also useful for the production of wild-type (“native”) phage and phage cocktails comprising different types of phage. Embodiments enable production of compositions of such particles for use in medical, environmental or food production settings.
Claims20
A method of producing transduction particles wherein the particles are capable of recognizing a receptor on bacterial target cells for transduction of the cells, the method comprising producing the particles in bacterial producer cells, wherein the bacterial producer cells do not express the receptor on their surface,
- wherein the production yield of transduction particles is enhanced compared to production in bacterial producer cells that express the receptor on their surface.
Dependencies are inferred from the claim text.