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US 12,528,779 B2Granted
Heterocyclic compounds and related methods
AssigneeRecursion Pharmaceuticals, Inc.
InventorsMichael James Genin, Joseph Carpenter, Carl Brooks
Life of this patent
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Abstract
Provided herein are compounds of Formula (I) and Formula (II) and stereoisomers, tautomers, and pharmaceutically acceptable salts or solvates thereof. Also provided are pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition by using the compounds and pharmaceutical compositions.
Claims9
A compound of Formula (I) or Formula (II):
- or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof;
- wherein X1, X2, and X3 are each independently CR2, N, NR5, O, or S;
- Y1, Y2, and Y3 are each independently CR2, or N, provided that at least one Y1, Y2, and Y3 is N;
- X4 and X5 are each independently C or N;
- m is an integer of 0, 1, or 2;
- Z is a 6- to 10-membered aryl or 5- to 10-membered heteroaryl containing 1 to 3 heteroatoms independently selected from N, O, and S;
- R1 and R2 are each independently hydrogen, halo, cyano, hydroxyl, amino, C1-6 alkyl, alkylamino, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkoxyalkyl, alkoxy, or haloalkoxy;
- R3 is hydrogen;
- R4 is
- R5 is hydrogen, halo, cyano, hydroxyl, amino, C1-6 alkyl, alkylamino, haloalkyl, hydroxyalkyl, hydroxycycloalkyl, aminoalkyl, alkoxyalkyl, haloalkoxyalkyl, alkoxy, haloalkoxy or —C(O)OR6;
- and
- R6 is hydrogen or C1-6 alkyl.
9 more elements
Dependencies are inferred from the claim text.