Quinazolinones derivatives for treatment of non-alcoholic fatty liver disease, preparation and use thereof
AssigneeCouncil of Scientific and Industrial Research
InventorsArindam Talukdar, Partha Chakrabarti, Dipayan Sarkar, Saheli Chowdhury, Sunny Goon, Subrata Das, Nirmal Das, Dipika Sarkar
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Abstract
Compounds having Structure I are provided for treating diseases and disorders for which inhibition or modulation of the Ubiquitin Ligase COP1 enzyme produces a physiologically beneficial response, in particular for the treatment of Non-Alcoholic Fatty Liver Disease (NAFLD). These compounds having Structure I are capable of increasing the level of adipose triglyceride lipase (ATGL). Also provided is the process of preparing compounds having Structure I.
Claims9
A compound having Structure I or salts thereof,
- where:
- R1 is independently selected from the group consisting of —H,
- R2 is independently selected from the group consisting of
- R3 is independently selected from the group consisting of,
- R4 is independently selected from the group consisting of —H,
- and
- R5 is independently selected from the group consisting of
Dependencies are inferred from the claim text.