Hollow fiber membrane for separating blood plasma from blood
AssigneeFresenius Medical Care Deutschland GmbH
InventorsDietmar Hansel, Michael Paul
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Abstract
A hollow fiber membrane for separating blood plasma from blood, comprising a blood contact layer and a support layer each comprising a hydrophobic polymer, a hydrophilic polymer and vitamin E, and a method for producing said hollow fiber membrane to provide a hollow fiber membrane is described. The hollow fiber membrane is characterized by a reduced hemolysis activity so that the hollow fiber membrane can be advantageously used in plasmapheresis methods.
Claims18
A hollow fiber membrane for the separation of blood plasma from blood, comprising a blood contact layer and a support layer, each comprising a hydrophobic polymer, a hydrophilic polymer and vitamin E, wherein the vitamin E is present in an amount of 0.005 to 0.25 wt. % relative to the total weight of the hollow fiber membrane, the hydrophobic polymer comprises polysulfone and the hydrophilic polymer comprises polyvinylpyrrolidone, the blood contact layer in a near-surface layer, determined by XPS measurement, has a polyvinylpyrrolidone content of 35 to 60 wt. %, and wherein
- the hollow fiber membrane has a sieving coefficient for albumin, determined according to DIN EN ISO 8637-3:2018, of 50 to 100%, or wherein
- the hollow fiber membrane has a sieving coefficient for immunoglobulin M, determined according to DIN EN ISO 8637-3:2018, of 50 to 100%, or wherein
- the hollow fiber membrane has a sieving coefficient for low density lipoprotein, determined according to DIN EN ISO 8637-3:2018, of 80 to 100%.
A hollow fiber membrane for the separation of blood plasma from blood, comprising a blood contact layer and a support layer, each comprising a hydrophobic polymer, a hydrophilic polymer and vitamin E, wherein the vitamin E, is present in an amount of 0.005 to 0.25 wt. % relative to the total weight of the hollow fiber membrane, the blood contact layer and the support layer are porous layers, the hydrophilic polymer comprises polyvinylpyrrolidone, and the blood contact layer in a near-surface layer, determined by XPS measurement, has a polyvinylpyrrolidone content of 35 to 55 wt. % and wherein
- the hollow fiber membrane has a sieving coefficient for albumin, determined according to DIN EN ISO 8637-3:2018, of 50 to 100%, or wherein
- the hollow fiber membrane has a sieving coefficient for immunoglobulin M, determined according to DIN EN ISO 8637-3:2018, of 50 to 100%, or wherein
- the hollow fiber membrane has a sieving coefficient for low density lipoprotein, determined according to DIN EN ISO 8637-3:2018, of 80 to 100%.
Dependencies are inferred from the claim text.