Cyanine-based telodendrimers and uses for treating cancer

A nanoparticle comprising a plurality of first conjugates and further comprising a plurality of second conjugates, wherein each first conjugate is independently a compound of formula (I):

• wherein:
• PEG is a polyethylene glycol (PEG) polymer, wherein each PEG polymer has a molecular weight of 1-10 kDa;
• each X is independently 2,3-diamino propanoic acid, 2,4-diaminobutanoic acid, 2,5-diaminopentanoic acid (ornithine), 2,6-diaminohexanoic acid (lysine), (2-Aminoethyl)-cysteine, 3-amino-2-aminomethyl propanoic acid, 3-amino-2-aminomethyl-2-methyl propanoic acid, 4-amino-2-(2-aminoethyl) butyric acid, or 5-amino-2-(3-aminopropyl) pentanoic acid;
• each R1 is independently cholic acid (3α, 5β, 7α, 12α)-7,12-dihydroxy-3-(2,3-dihydroxy-1-propoxy)-cholic acid (CA-4OH), (3α, 5β, 7α, 12α)-7-hydroxy-3,12-di(2,3-dihydroxy-1-propoxy)-cholic acid (CA-5OH), or (3α, 5β, 7α, 12α)-7,12-dihydroxy-3-(3-amino-2-hydroxy-1-propoxy)-cholic acid (CA-3OH—NH2);
• and
• each R2 is independently cyanine 3, cyanine 3.5, cyanine 5, cyanine 5.5, cyanine 7, cyanine 7.5, indocyanine green, or a indocyanine green derivative with a structure (S1):
• wherein each second conjugate is independently a compound of formula (II):
• wherein:
• PEG is a polyethylene glycol (PEG) polymer, wherein each PEG polymer has a molecular weight of 1-10 kDa;
• each X is independently 2,3-diamino propanoic acid, 2,4-diaminobutanoic acid, 2,5-diaminopentanoic acid (ornithine), 2,6-diaminohexanoic acid (lysine), (2-Aminoethyl)-cysteine, 3-amino-2-aminomethyl propanoic acid, 3-amino-2-aminomethyl-2-methyl propanoic acid, 4-amino-2-(2-aminoethyl) butyric acid, or 5-amino-2-(3-aminopropyl) pentanoic acid;
• each Y is independently cystein;
• each L is independently an Ebes linker having the formula
• and
• each R1 is independently cholic acid, (3α, 5β, 7α, 12α)-7,12-dihydroxy-3-(2,3-dihydroxy-1-propoxy)-cholic acid (CA-4OH), (3α, 5β, 7α, 12α)-7-hydroxy-3,12-di(2,3-dihydroxy-1-propoxy)-cholic acid (CA-5OH), or (3α, 5β, 7α, 12α)-7,12-dihydroxy-3-(3-amino-2-hydroxy-1-propoxy)-cholic acid (CA-3OH—NH2), and
• wherein:
• the plurality of conjugates self-assembles in an aqueous solvent to form the nanoparticle such that a hydrophobic core is formed in the interior of the nanoparticle, wherein the PEG of each conjugate self-assembles on the exterior of the nanoparticle.