Toothpaste for delivery of allergens to oral mucosa
AssigneeAllovate, LLC
InventorsMichael Nelson, Erick Berglund
Life of this patent
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Abstract
Pro-toothpaste compositions formulated to receive a volume of allergen solution to provide toothpastes that exhibit efficacy for oral mucosal immunotherapy (OMIT) and acceptable consumer and product stability properties, along with kits of pro-toothpaste, allergen/extracts of allergens, and optionally compounding means and/or specialized toothbrushes are provided. Toothpastes suitable and effective for OMIT and methods for managing allergic symptoms and for reducing risk of allergy in people without symptoms employing the pro-toothpastes, toothpastes, and kits of the invention are also disclosed.
Claims20
An oral mucosal therapy kit comprising:
- at least one vial of pro-toothpaste comprising:
- from about 40% to about 60% by volume glycerol;
- from about 12% to about 30% by weight of a silica-based viscosity modifier;
- and
- from about 0.2% to about 0.5% by weight of sodium fluoride;
- and
- at least one separate vial comprising at least one allergen or allergen extract suspended in a solution comprising glycerol;
- wherein a concentration of glycerol in the allergen or allergen extract solution corresponds to a concentration of glycerol in the pro-toothpaste.
A method for formulating a toothpaste suitable for oral mucosal therapy, the method comprising:
- providing a first volume of a solution comprising an allergen or allergen extract and a concentration of glycerol;
- formulating a second volume of a pro-toothpaste comprising:
- a concentration of glycerol substantially corresponding to the concentration of glycerol of the first volume;
- and
- sodium fluoride;
- and
- mixing the first and second volumes together to provide the toothpaste composition suitable for oral mucosal therapy,
- wherein the combined volume of glycerol in the toothpaste composition is from about 40% to about 55% by volume.
Dependencies are inferred from the claim text.