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US 12,527,853 B2Granted
Heat-stable enterotoxins mutants as antidiarrheal vaccine antigens
AssigneeVestlandets Innovasjonsselskap AS (VIS)
InventorsPål Puntervoll, Françoise Baleux, Yves-Marie Coïc, Yuleima Diaz, Morten Andreas Govasli Larsen, Laurence Mulard, Arne Taxt, Ephrem Debebe Zegeye, Sandhya Srikant Visweswariah, Vishwas Mishra, Anaxee Barman
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Abstract
The present invention relates to mutants of an E. coli heat-stable toxin (ST) having the following wild-type sequence: NSSNYCCELCCNPACTGCY wherein the mutant has two mutations wherein the first mutation is selected from L9K, L9N and L9T and the second mutation is A14T.
Claims8
A mutant of an E. coli heat-stable toxin (ST) having the following wild-type sequence:
- (SEQ ID NO:
- 1)
- NSSNYCCELCCNPACTGCY
- wherein the mutant has two mutations wherein the first mutation is L9K and the second mutation is A14T.
1 more element
Dependencies are inferred from the claim text.