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US 12,527,836 B2Granted
Gla domains as targeting agents
AssigneeGladiator Biosciences, Inc.
InventorsMaxine Bauzon, Terry Hermiston
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Abstract
The disclosure relates to the recombinant Gla domain proteins and their use targeting phosphatidylserine (PtdS) moieties on the surface of cells, particularly those expressing elevated levels of PtdS, such as cells undergoing apoptosis. These proteins can be linked to both diagnostic and therapeutic payloads, thereby permitting identification and treatment of cells expression elevated PtdS.
Claims15
A polypeptide suitable for targeting phosphatidylserine cell-surface expression, said polypeptide comprising:
- a protein S gamma-carboxyglutamic-acid (Gla) domain,
- a protein S EGF domain, and
- wherein the polypeptide lacks a protease domain, lacks a hormone-binding domain, and comprises SEQ ID NO:
- 6 or the fragment thereof lacking the His tag;
- and
- said polypeptide is genetically fused or conjugated to a payload that is a therapeutic payload.
3 more elements
Dependencies are inferred from the claim text.