# US 12,527,824 B2 · Strain of Bifidobacterium animalis subsp. lactis HEM20-01 and composition for treating depression, comprising the same or its culture fluid

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- Number: US 12,527,824 B2
- Document ID: US12527824B2
- Status: Granted
- Kind: B2
- Application number: 18/259,441
- Filed: 2021-12-14
- Published: 2024-02-22
- Granted: 2026-01-20
- Earliest claimed: 2020-12-28
- Assignees: Hem Pharma Inc.
- Applicants: Hem Pharma Inc.
- Inventors: So Young Park; Yo Sep Ji
- Web page: https://patentgrep.com/patent/US12527824B2

## CPC

- A23L 33/135: Bacteria or derivatives thereof, e.g. probiotics
- A61K 35/745: Bifidobacteria
- A61P 25/24: Antidepressants
- C12N 1/205: Bacterial isolates
- A23V 2200/322: having an effect on the health of the nervous system or on mental function
- A61K 2035/115: {Probiotics}
- C12R 2001/01: Bacteria or Actinomycetales {; using bacteria or Actinomycetales}
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- C12R: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS

## Abstract

The present disclosure relates to a strain of Bifidobacterium animalis subsp. lactis HEM20-01 (KCTC14143BP) and a composition for treating, preventing or alleviating depression, comprising the same. A strain of Bifidobacterium animalis subsp. lactis HEM20-01 (KCTC14143BP) according to an embodiment of the present disclosure can treat or prevent depression by reducing corticosterone, endotoxin and pro-inflammatory cytokines. Therefore, the strain can be applied to pharmaceutical compositions, food compositions, health functional food compositions, and the like for treating or preventing depression.

## Claims

### Claim 1

A strain of Bifidobacterium animalis subsp. lactis HEM20-01 deposited under accession no. KCTC14143BP at the Korean Collection for Type Cultures, wherein the strain is lyophilized.

### Claim 2 (depends on 1)

A food composition comprising a strain of claim 1 or its culture fluid as an active ingredient.

### Claim 3 (depends on 1)

A pharmaceutical composition comprising a strain of claim 1 or its culture fluid as an active ingredient.