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US 12,527,821 B2Granted
Compositions and methods related to tumor cell killers and vaccines
AssigneeThe Brigham and Women's Hospital, Inc.
InventorKhalid Shah
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Abstract
Described herein are methods and compositions for treating cancer. Various embodiments use engineered autologous or syngeneic cancer cells that home to tumors in vivo and deliver therapeutic polypeptides. Various embodiments further promote an anti-tumor immune response that can assist in treating existing tumors and provide protection against recurrent cancer.
Claims10
A tumor cell engineered to express heterologous polypeptides including:
- (i) an IFN-β polypeptide;
- (ii) a Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) polypeptide;
- and
- (iii) a heterologous inducible cell suicide system;
- wherein the cell is further engineered to inactivate endogenous receptor for the IFN-β polypeptide.
2 more elements
Dependencies are inferred from the claim text.