Treatment of an ocular infection, composition and methods thereof
AssigneesThe University of Hong Kong, City University of Hong Kong
InventorsLee Lee Teng, Patrick Chiu Yat Woo, Ying Tang, Susanna Kar Pui Lau, Man Lung Yeung, Elaine Chan, Terrence Chi Kong Lau
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Abstract
The present disclosure relates to a method to reduce virulence of Tsukamurella comprising decreasing the expression of the mycolyltransferase C (‘tmytC”) gene. Also disclosed is a pharmaceutical composition and method of prevention and treatment of infection by inhibition of tmytC.
Claims12
A method of treating an ocular bacterial infection caused by Tsukamurella in a subject comprising a step of administering to an eye of the subject an ophthalmic composition comprising
- polyhexamethylene biguanide (“PHMB”) at a concentration of at least 0.0025 wt %, and
- one or more tmytC inhibitor of the formula:
A method of treating an ocular bacterial infection caused by Tsukamurella comprising a step of treating a contact lens prior to wearing the contact lens by a subject with a composition comprising polyhexamethylene biguanide (“PHMB”) at a concentration of at least 0.0025 wt %, and
- one or more tmytC inhibitor of the formula:
Dependencies are inferred from the claim text.