Inhibition of a tripartite VOR protein complex in multicellular organisms
AssigneesAurelio Lorico, Mark Santo, Germana Rappa, Patrizia Diana, Technische UniversitäT Dresden, Basck Invest Limited, Giuseppe Pizzorno, Andrea Dagnino, Ottavio Dagnino, Baldesare Renda, Gaspare Spedale
InventorsAurelio Lorico, Denis Corbeil, Mark F. Santos, Germana Rappa
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Abstract
The present disclosure relates generally to methods of inhibiting a tripartite VAP-A, ORP3 and Rab7 (VOR) protein complex in multicellular organisms, to methods of identifying agents which inhibit such complex and to the medical use of those agents. Inhibition of the VOR complex causes interference with at least one mechanism of intercellular communication, wherein the intercellular communication is mediated by receptor-ligand interaction and/or EVs, and viral infection involving the transport of endocytosed biomaterials to the nucleus of recipient cells.
Claims5
A method of inhibiting at least one member of a tripartite VAP-A, ORP3 and Rab7 (VOR) protein complex in multicellular organisms, for use in therapeutic intervention, wherein the method comprises:
- selecting a compound for targeting the VOR protein complex, such that the inhibition causing interference with at least one mechanism of:
- (a) intercellular communication, wherein the intercellular communication is mediated by receptor-ligand interaction and/or EVs;
- or
- (b) viral infection involving the transport of endocytosed biomaterials to the nucleus of recipient cells,
- the method further comprising mixing the chemical compound with the tripartite VAP-A, ORP3 and Rab7 (VOR) protein complex,
- wherein the chemical compound is Itraconazole or Itraconazole salt thereof or an Itraconazole analogue or Itraconazole analogue salts thereof.
Dependencies are inferred from the claim text.