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US 12,527,758 B2Granted
Use of itaconate and its derivatives/analogues to induce hair growth
AssigneeThe Johns Hopkins University
InventorsLuis Garza, Mohameed Islam, Barbara Slusher, Rana Rais
Life of this patent
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Abstract
Methods for the use of prodrugs of itaconic acid and 1- and 4-methyl itaconic acid for inducing hair growth and treating an inflammatory, or immune activation (adaptive or innate), skin condition or other condition associated with hair loss are disclosed.
Claims13
A method for treating alopecia areata in a subject in need of treatment thereof, the method comprising administering to the subject a therapeutically effective amount of a compound of formula (I):
- wherein R1 and R2 are selected from one of the following combinations:
- (a) R1 is —OR3 and R2 is selected from
- wherein R7 is selected from —C(═O)—O—R8,
- (b) R1 is
- and R2 is selected from —OR3,
- wherein R7 is selected from —C(═O)—O—R8,
- (c) R1 is
- and R2 is selected from —OR3,
- wherein R7 is selected from —C(═O)—O—R8,
- (d) R1 is
- and R2 is selected from —OR3,
- wherein R7 is selected from —C(═O)—O—R8
- (e) R1 is
- and R2 is selected from —OR3,
- wherein R7 is selected from —C(═O)—O—R8,
- (f) R1 is
- wherein R7 is —C(═O)—O—R8 and R2 is selected from —OR3,
- wherein R7 is selected from —C(═O)—O—R8,
- (g) R1 is
- wherein R7 is
- and R2 is selected from —OR3,
- wherein R7 is selected from —C(═O)—O—R8,
- (h) R1 is
- wherein R7 is
- and R2 is selected from —OR3,
- wherein R7 is selected from —C(═O)—O—R8,
- and
- (i) R1 is
- wherein R7 is
- and R2 is selected from —OR3,
- wherein R7 is selected from —C(═O)—O—R8,
- wherein:
- n is an integer selected from 1, 2, 3, and 4;
- m is an integer selected from 1, 2, 3, and 4;
- p is an integer selected from 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 and 20;
- q is an integer selected from 1,2,3,4, 5, 6, 7, 8, 9, and 10;
- r is 1;
- u is an integer selected from 1, 2, 3, and 4;
- R3 is H or C1-C6 straight-chain or branched unsubstituted or substituted alkyl;
- R4 is —OR5,
- wherein R5 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl;
- R6 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl;
- R8 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl;
- R9 is H or C1-C4 straight-chain or branched unsubstituted or substituted alkyl;
- R10 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl;
- R11 and R12 are each independently H or a protecting group;
- R13 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl;
- R14 is H or C1-C4 straight-chain or branched unsubstituted or substituted alkyl;
- R15 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl;
- and
- R16 and R17 are each independently selected from H, C1-C4 straight-chain or branched unsubstituted or substituted alkyl, and a protecting group;
- R18 is aryl;
- R19 is C1-C4 straight-chain or branched unsubstituted or substituted alkyl;
- R20 is H or C1-C4 straight-chain or branched unsubstituted or substituted alkyl;
- and
- R21 is —OR22, wherein R22 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl or R21 is —NR23R24, wherein R23 and R24 are each independently H or C1-C4 straight-chain or branched unsubstituted or substituted alkyl;
- and pharmaceutically acceptable salts thereof.
54 more elements
Dependencies are inferred from the claim text.