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US 12,527,752 B2Granted
Composition based on gellan gum and phenylephrine, production method and use as an ophthalmic product
AssigneeUnither Pharmaceuticals
InventorsPierre-Louis Destruel, Vincent Boudy, Ni Zeng, Nathalie Mignet, Marc Maury
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Abstract
The invention relates to a specific composition comprising in particular at least gellan gum and phenylephrine. It also relates to a particular method for manufacturing such a composition and its uses in particular as a mydriatic ophthalmic product.
Claims19
A composition in the form of a solution having a viscosity of less than or equal to 500 mPa·s at a temperature between 20° and 25° C., consisting of:
- gellan gum,
- phenylephrine or phenylephrine in combination with tropicamide,
- sodium citrate in an amount ranging from 0.01 to 0.2% w/v as a gelation regulating agent,
- a cellulose derivative in an amount 0 to 2% w/v;
- a chelating agent in an amount 0 to 0.2% w/v;
- and
- water;
- and
- wherein after the composition is applied to the eye, the composition has a gel viscosity at rest when the eye is open and a lower viscosity under the eyelid shear, thereby decreasing eye irritation and discomfort.
6 more elements
Dependencies are inferred from the claim text.