Vapor phase coatings for pharmaceutical solubility control
AssigneeApplied Materials, Inc.
InventorColin C. Neikirk
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Abstract
A method of preparing a pharmaceutical composition having a drug-containing core enclosed by one or more metal oxide materials is provided. The method includes the sequential steps of (a) loading the particles comprising the drug into a reactor, (b) applying a vaporous or gaseous metal precursor to the particles in the reactor, (c) performing one or more pump-purge cycles of the reactor using inert gas, (d) applying a vaporous or gaseous oxidant to the particles in the reactor, and (e) performing one or more pump-purge cycles of the reactor using inert gas. The temperature of the particles does not exceed 35° C. This produces a pharmaceutical composition comprising a drug containing core enclosed by one or more metal oxide materials.
Claims15
A method of preparing particles comprising a drug-containing core enclosed by a combination of, conformal organic and inorganic coatings each having a thickness of less than 100 nm, the inorganic coatings comprise one or more metal oxide materials, the method comprising the sequential steps of:
- (a) loading the particles comprising the drug into a reactor;
- (b) applying a vaporous or gaseous metal precursor to the particles in the reactor;
- (c) performing one or more pump-purge cycles of the reactor using inert gas;
- (d) applying a vaporous or gaseous oxidant to the particles in the reactor;
- (e) performing one or more pump-purge cycles of the reactor using inert gas;
- and
- (f) applying one or more organic coatings through molecular layer deposition (MLD);
- thereby producing particles comprising a drug containing core enclosed by a combination of thin, conformal organic and inorganic coatings, each having a thickness of less than 100 nm.
Dependencies are inferred from the claim text.