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US 12,527,729 B2Granted
Minoxidil adjuvant therapies
AssigneeCaring Brands, Inc.
InventorsOfer A. Goren, John McCoy
Life of this patent
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AssigneeCaring Brands, Inc.
InventorsOfer A. Goren, John McCoy
Estimating the term…
Compositions and methods are disclosed herein for inducing (up-regulating) the expression of sulfotransferases in the hair follicles, e.g., the scalp. Increasing sulfotransferase is beneficial for metabolizing pro-drugs that require sulfonation to be activated, e.g., minoxidil sulfate is the active metabolite of minoxidil. A method for combining the compositions described herein with topical minoxidil to enhance minoxidil treatment for androgenetic alopecia is described. Additional methods and compositions include the use of retinoid X receptor agonists, retinoic acid receptor agonists, and nuclear receptor agonists in an RXR-NR heterodimer. Additional methods and compositions include the use of a topical solution containing an alkalinizing agent or an alkalinizing agent used with a penetration enhancer for up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells. In addition, compositions and methods for increasing or decreasing the growth rate of hair follicles is disclosed by altering the intracellular pH.
A composition for treating hair loss, improving hair growth, accelerating hair growth, increasing the sulfonating capacity of a hair follicle cell and/or keratinocyte cell, inducing sulfotransferase in a hair follicle, inducing expression of sulfotransferase, increasing hair thickness and/or diameter, increasing hair growth rate, increasing hair density, accelerating hair growth, treating for alopecia, upregulating sulfotransferase, converting non-responders to minoxidil responders, and/or improving minoxidil response, the composition comprising:
A method for treating hair loss, improving hair growth, accelerating hair growth, increasing the sulfonating capacity of a hair follicle cell and/or keratinocyte cell, inducing sulfotransferase in a hair follicle, inducing expression of sulfotransferase, increasing hair thickness and/or diameter, increasing hair growth rate, increasing hair density, accelerating hair growth, treating for alopecia, upregulating sulfotransferase, converting non-responders to minoxidil responders, and/or improving minoxidil response, the method comprising:
Dependencies are inferred from the claim text.