Dissolvable medical device for drugs delivery
AssigneeAlcon Inc.
InventorsHoward Allen Ketelson, Rekha Rangarajan
Life of this patent
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Abstract
A dissolvable medical device for placing on the outer exposed surface of the eye to deliver a drug to the eye comprises: a polymeric film has sufficient dimensions to cover a cornea when applied to an eye and the polymeric film comprising one or more mucoadhesive polymers. The polymeric film dissolves between 15 minutes to 120 minutes to release the mucoadhesive and the pharmaceutically active agents after applying the polymeric film to the eye. The dissolved polymeric film is not impeding visualization of ocular tissue while maintaining a protective film on outer surface of the eye.
Claims10
A dissolvable medical device for placing on the outer exposed surface of the eye to deliver a drug to the eye comprising:
- a polymeric film has sufficient dimensions to cover a cornea when applied to an eye, wherein the polymeric film is circular and has a diameter 11 mm to 13 mm and a thickness 120 um-250 um, wherein the polymeric film comprising one or more mucoadhesive polymers, wherein the one or more mucoadhesive polymers are hydroxypropyl guar (HP guar), hyaluronic acid, or sodium hyaluronate or polyvinyl pyrrolidine or combinations thereof, wherein the polymeric film dissolves between 15 minutes to 120 minutes to release the mucoadhesive and the pharmaceutically active agents after applying the polymeric film to the eye, wherein a pharmaceutically active agent is added in the polymeric film during manufacturing the polymeric film or onto the polymeric film after the polymeric film is placed on the outer surface of the eye or onto the polymeric film after manufacturing but before placing on the outer surface of the eye, wherein the dissolved polymeric film is not impeding visualization of ocular tissue while maintaining a protective film on outer surface of the eye, wherein the pharmaceutically active agent is phenylephrine, wherein the dissolvable medical device comprising 0.0025% w/w to 2.5% w/w of phenylephrine, wherein comparing to apply the same amount of the phenylephrine to the cornea and wait for exact 10 minutes to measure, a pupil is dilated to a bigger size when the phenylephrine is delivered in the presence of the polymeric film than in the absence of the polymeric film.
Dependencies are inferred from the claim text.