Precise ablation treatment of cancer using the synergetic effects of electromagnetic radiation with nanoparticles

A device for ablation-based cancer treatment, the device comprising:

• at least one Radio Frequency coil configured to generate alternating RF magnetic fields;
• at least one microwave antenna configured to generate microwave electromagnetic waves which cause a maximal specific loss power in a tumor region of a subject and minimal specific loss power in a healthy tissue of the subject which is in proximity to the tumor region, wherein the RF magnetic fields and microwave electromagnetic waves are configured to be absorbed by, and thereby heat, metallic nanoparticles configured to selectively accumulate in the tumor regions;
• and
• a control circuitry configured to:
• provide an electrical signal at a radio frequency to said at least one radio frequency coil, to thereby define properties of the RF magnetic fields generated by said at least one radio frequency coil;
• provide an electrical signal at a microwave frequency to said at least one microwave antenna, to thereby define properties of the microwave electromagnetic waves generated by said at least one microwave antenna;
• obtain temperature information from a thermal sensor located in the tumor region and from a thermal sensor located in the healthy tissue;
• and
• adjust one or more properties of the RF magnetic fields and/or microwave electromagnetic waves based on the obtained temperature information, to ensure that the combination of the RF magnetic fields and the microwave electromagnetic waves cooperate to heat the tumor region to an ablative temperature without substantially heating the healthy tissue which is in proximity to the tumor region.