High hyaluronate multi-purpose disinfection solutions for ophthalmic applications
AssigneeCIS Biopharma AG
InventorsChristian Geraths, Rolf Schafer
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Abstract
The present invention relates to ophthalmic formulations wherein a synergistic combination of three different classes of disinfectants (a multimeric biguanide compound, a quaternary ammonium compound and an antifungal/anti-acanthamoeba compound, in particular a combination of polyhexamethylene biguanide, Polyquaternium-1 and myristamidopropyl dimethylamine) enables the use of high concentrations of hyaluronate for providing better comfort and support of corneal health without compromising antimicrobial efficacy. The novel ophthalmic formulations support the use of more than 7.5 times higher concentrations of hyaluronate than are present in currently marketed multi-purpose disinfection solutions.
Claims22
A solution comprising a multimeric biguanide compound in an amount ranging from about 0.00005 to about 0.0005% w/v, a quaternary ammonium compound in an amount ranging from about 0.00005 to about 0.0025% w/v, an antifungal/anti-acanthamoeba agent in an amount ranging from about 0.00005 to about 0.0025% w/v, wherein the antifungal/anti-acanthamoeba agent is an amido-amine compound, and hyaluronic acid or a salt thereof in an amount ranging from about 0.015 to about 0.1% w/v.
Dependencies are inferred from the claim text.