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US 12,523,670 B2Granted
Method and apparatus for automated sample preparation
AssigneeLife Technologies Corporation
InventorsKristopher Barbee, Ray Wheeling, Nicholas Peter Bajka, Maximilian Carpino
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Abstract
The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.
Claims19
A method for preparing a biological sample for analysis, the method comprising:
- forming a sample including a liquid portion and a bead complex, the bead complex comprising a first bead captured by a second bead, wherein the first bead carries amplified copies of a sample template nucleic acid, and wherein the second bead is a magnetic bead and carries an adapter sequence;
- applying a magnetic field to the sample and thereby securing the bead complex within the magnetic field via magnetic attraction of the second bead to the magnetic field;
- and
- processing the bead complex secured within the magnetic field to cause separating of the first bead from the second bead.
1 more element
Dependencies are inferred from the claim text.