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US 12,522,855 B2Granted
Methods and kits for identifying thrombus origin and optimizing post-ischemic event treatment
AssigneeTel HaShomer Medical Research Infrastructure and Services Ltd.
InventorsDavid Orion, Zeev Itsekson-Hayosh, Efrat Shavit-Stein, Joab Chapman
Life of this patent
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Abstract
Provided herein are method and kits for identifying thrombus origin based on temporal thrombin activity assay, and use thereof for optimizing post-ischemic event treatment, and further preventing recurrence of secondary ischemic events.
Claims9
A method for identifying thrombus origin, the method comprising
- (a) incubating a sample of a thrombus in a reaction buffer;
- and
- (b) determining the level of thrombin in the reaction buffer at a plurality of time points;
- wherein the thrombus is a thrombus obtained from a subject following ischemic event, and
- wherein the method further comprises adding a thrombin substrate to the reaction buffer prior to said determining and/or
- further comprising removing the sample of the thrombus from the reaction buffer prior to step (b) or prior to said adding.
3 more elements
Dependencies are inferred from the claim text.