Processes and systems for preparing cellular or viral membranes and nanoparticles
AssigneeArytha Biosciences, LLC
InventorsWeiwei Gao, Che-Ming Jack Hu
Life of this patent
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Abstract
The present invention relates to processes and systems for preparing nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles using or comprising, inter alia, a multi-inlet vortexing reactor, tangential flow filtration (TFF) and/or a high shear fluid processor such as a microfluidizer (or a microfluidizer processor). The present invention also relates to the nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles prepared by the present processes and systems, and the uses and/or applications of the nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles.
Claims20
A process for preparing a nanoparticle, which process comprises:
- 1) mixing a polymer for forming a nanoparticle in an organic solvent and an aqueous phase comprising water or a water-based buffer using a multi-inlet vortexing reactor to form a composition comprising said nanoparticle wherein said organic solvent dissolves said polymer and is miscible with water;
- and
- 2) subjecting said composition to tangential flow filtration (TFF) to remove said organic solvent from said composition.
Dependencies are inferred from the claim text.