Zwitterion compound and production method and use for same
AssigneeTokushima University
InventorsMikito Yasuzawa, Tsubasa Miki, Yukihiro Arakawa, Yasushi Imada, Hitoshi Matsuki
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Abstract
An object is to provide a zwitterionic compound having an excellent protein adsorption inhibitory effect. The zwitterionic compound is a polymer comprising a unit represented by the following formula (1): wherein R1 is a hydrogen atom or a methyl group, R2 is OH or O−, X1 is —O— or —N(Q1)-, Q1 is a hydrogen atom or a C1-6 alkyl group, m is an integer of 1 to 12, and n is an integer of 1 to 4.
Claims5
A polymer comprising a unit represented by the following formula (1):
- wherein
- R1 is a hydrogen atom or a methyl group,
- R2 is OH or O−,
- X1 is —O— or —N(Q1)-,
- Q1 is a hydrogen atom or a C1-6 alkyl group,
- m is an integer of 1 to 12, and
- n is an integer of 1 to 4,
- (i) wherein the percentage of the unit is more than 90 mol % based on the total monomer units, or
- (ii) wherein the polymer further comprises a unit represented by the following formula (2):
- wherein
- R3 is —CO—X2—R4 or —CH2—CO—X2—R4, and R4 is a C1-16 alkyl group,
- X2 is —O— or —N(Q2)-, and
- Q2 is a hydrogen atom or a C1-6 alkyl group, and
- wherein the molar ratio of the unit represented by formula (1) and the unit represented by formula (2) is 10:90 to 35:65.
A film or sheet containing a polymer comprising a unit represented by the following formula (1):
- wherein
- R1 is a hydrogen atom or a methyl group,
- R2 is OH or O−,
- X1 is —O— or —N(Q1)-,
- Q1 is a hydrogen atom or a C1-6 alkyl group,
- m is an integer of 1 to 12, and
- n is an integer of 1 to 4,
- (i) wherein the percentage of the unit is more than 90 mol % based on the total monomer units, or
- (ii) wherein the polymer further comprises a unit represented by the following formula (2):
- wherein
- R3 is a hydrogen atom or a methyl group, and R4 is a C3-16 alkyl group, or
- R3 is —CO—X2—R4 or —CH2—CO—X2R4, and R4 is a C1-16 alkyl group,
- X2 is —O— or —N(Q2)-, and
- Q2 is a hydrogen atom or a C1-6 alkyl group, and
- wherein the molar ratio of the unit represented by formula (1) and the unit represented by formula (2) is 10:90 to 35:65.
A method for imparting biocompatibility to a material or enhancing biocompatibility of a material, the method comprising applying to a surface of the material a polymer comprising a unit represented by the following formula (1):
- wherein
- R1 is a hydrogen atom or a methyl group,
- R2 is OH or O−,
- X1 is —O— or —N(Q1)-,
- Q1 is a hydrogen atom or a C1-6 alkyl group,
- m is an integer of 1 to 12, and
- n is an integer of 1 to 4,
- (i) wherein the percentage of the unit is more than 90 mol % based on the total monomer units, or
- (ii) wherein the polymer further comprises a unit represented by the following formula (2):
- wherein
- R3 is a hydrogen atom or a methyl group, and R4 is a C3-16 alkyl group, or
- R3 is —CO—X2—R4 or —CH2—CO—X2R4, and R4 is a C1-16 alkyl group,
- X2 is —O— or —N(Q2)-, and
- Q2 is a hydrogen atom or a C1-6 alkyl group, and
- wherein the molar ratio of the unit represented by formula (1) and the unit represented by formula (2) is 10:90 to 35:65.
A method for imparting biocompatibility to a material or enhancing biocompatibility of a material, the method comprising applying to a surface of the material a polymer comprising a unit represented by the following formula (1):
- wherein
- R1 is a hydrogen atom or a methyl group,
- R2 is OH or O−,
- X1 is —O— or —N(Q1)-,
- Q1 is a hydrogen atom or a C1-6 alkyl group,
- m is an integer of 1 to 12, and
- n is an integer of 1 to 4,
- wherein the material is a liquid for preserving contact lens, a surface-modifying material for a diagnostic medical device, a cell culture sheet, a material for preserving blood, a protein or a cell, a material for protein anticoagulation, a moisturizer, or a material for a facial mask.
Dependencies are inferred from the claim text.