Therapeutic targeting of Cadherin 11 in cancer
AssigneesThe General Hospital Corporation, The Brigham and Women's Hospital, Inc.
InventorsDaniel A. Haber, Michael Brenner, Shyamala Maheswaran, David T. Ting, Douglas Micalizzi
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Abstract
The present invention relates to methods, uses, and compositions for the treatment of cancer (e.g., a breast cancer or a pancreatic cancer). More specifically, the invention concerns the treatment of patients having cancer for the therapeutic inhibition of cancer cell growth and metastasis with an anti-Cadherin 11 monoclonal antibody with specific monoclonal antibody clones 23C6 or 3H10.
Claims22
A method for treating or delaying progression of a cancer in an individual, said method comprising administering to the individual an effective amount of an antibody that binds cadherin-11 (CDH11) comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 1;
- a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
- 2;
- a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
- 3;
- a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 4;
- a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
- 5;
- and
- a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 6;
- wherein the cancer expresses CDH11.
Dependencies are inferred from the claim text.