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US 12,522,651 B2Granted
BCG car constructs and methods of their manufacture and use
AssigneeVersiti Blood Research Institute Foundation, Inc.
InventorWeiguo Cui
Life of this patent
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Abstract
Provided herein are antibodies and antigen binding fragments thereof specific to BCG antigen Ag85B as well as chimeric antigen receptors and lymphocytes comprising Ag85B antibodies as described and methods of treating cancer and tuberculosis infections using the CAR lymphocytes described. In a first aspect, provided herein is an isolated antibody or antigen binding fragment thereof capable of binding Bacillus Calmette-Guerin (BCG) antigen Ag85B.
Claims20
An isolated antibody or antigen binding fragment thereof capable of binding Bacillus Calmette-Guerin (BCG) antigen Ag85B comprising:
- a light chain variable domain selected from the group consisting of (i) a light chain variable domain comprising a CDRL1 region of SEQ ID NO:20, a CDRL2 region of the amino acid sequence YAS, and a CDRL3 region of SEQ ID NO:21;
- (ii) a light chain variable domain comprising a CDRL1 region of SEQ ID NO:22, a CDRL2 region of the amino acid sequence YTS, and a CDRL3 region of SEQ ID NO:23;
- (iii) a light chain variable domain comprising a CDRL1 region of SEQ ID NO:24, a CDRL2 region of SEQ ID NO:25, and a CDRL3 region of SEQ ID NO:26;
- and (iv) a light chain variable domain comprising a CDRL1 region of SEQ ID NO:
- 27, a CDRL2 region of the amino acid sequence GTN, and a CDRL3 region of SEQ ID NO:
- 28;
- and
- a heavy chain variable domain selected from the group consisting of a heavy chain variable domain comprising a CDRH1 region of SEQ ID NO:15, a CDRH2 region of the amino acid sequence T, and a CDRH3 region of SEQ ID NO:16;
- and a heavy chain variable domain comprising a CDRH1 region of SEQ ID NO:17, a CDRH2 region of SEQ ID NO:18, and a CDRH3 region of SEQ ID NO:
- 19.
7 more elements
Dependencies are inferred from the claim text.