Heterodimeric FC cytokines and uses thereof
AssigneeSynthekine, Inc.
InventorsPatrick Lupardus, Deepti Rokkam
Life of this patent
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Abstract
The present disclosure provides IL12 and IL23 muteins as partial agonists comprising modified human p40 molecules that associate with human p35 (hP35) and human P19 (hP19) to form modified hIL-12 and IL23 partial agonists wherein the individual components of IL12 and IL23 muteins are linked to engineered Fc domains.
Claims19
A method of treating a mammal suffering from a neoplastic disease the method comprising the step of contacting the mammal with a pharmaceutically acceptable formulation comprising as an active ingredient a heterodimeric hIL12Fc mutein, wherein the heterodimeric hIL 12Fc mutein comprising a first polypeptide having the sequence of any one of SEQ ID NOS:
- 80, 83, 85, 86, 88, 90, 92, 121, 129, 132, 135, 138, 141, 144, 147, 150, and 153;
- and
- a second polypeptide having the sequence of any one of SEQ ID NOS:
- 81, 82, 84, 87, 89, 91, 93, and 124.
Dependencies are inferred from the claim text.