Aryl glucoside derivative and use thereof in drug
AssigneeShanghai Zheye Biotechnology Co. Ltd.
InventorsFengtian Du, Haibo Wang, Qiang Zhang
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Abstract
A compound inhibiting a sodium-glucose cotransporter 1, and a pharmaceutically acceptable salt and a stereoisomer thereof. The compound is used in a pharmaceutical composition. Also disclosed are methods for preparing and using the pharmaceutical composition, and an application in preparing a drug and a composition of the compound for treating and improving diabetes cardio-vascular diseases, weight reduction, fatty liver, astriction, and metabolism-related diseases, and cancer therapy.
Claims16
A compound of formula (II), a stereoisomer, tautomer or pharmaceutically acceptable salt thereof,
- wherein, X is selected from hydrogen, deuterium, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl, or C2-C6 alkynyl;
- R8, R9 are selected from hydrogen, deuterium, halogen, C1-C6 alkyl, or acyl;
- m2=0, 1, 2, 3;
- n2=1;
- Y is a linking group, which is a linking arm composed of 2 to 17 carbon, oxygen and nitrogen atoms.
A compound of formula (II-1), a stereoisomer, tautomer or pharmaceutically acceptable salt thereof,
- wherein, X is selected from hydrogen, deuterium, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl, or C2-C6 alkynyl;
- R8, R9 are each independently selected from hydrogen, deuterium, halogen, C1-C6 alkyl, cycloalkyl, cycloalkylalkyl acyl, or alkynylalkyl;
- m2=0, 1, 2, 3;
- n2=1;
- Y1 is a linking group selected from the following structures:
- wherein, RE, RF, RG, RH are each independently selected from hydrogen, deuterium, halogen, C1-C6 alkyl, or acyl;
- E, J are selected from chemical bonds, —CH2—, oxygen, or —NH—;
- s1=0, 1, 2, 3, 4, 5;
- s2=0, 1, 2, 3, 4, 5;
- s3=0, 1, 2, 3, 4, 5.
The following compounds, stereoisomers, tautomers or pharmaceutically acceptable salts thereof,
Dependencies are inferred from the claim text.