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US 12,522,611 B2Granted
Process for the preparation of high pure Eribulin and its Mesylate salt
AssigneeNatco Pharma Limited
InventorsPrabhakar Divya, Srinivasu Kasa, Durga Prasad Konakanchi, Ramesh Dandala, Pulla Reddy Muddasani, Venkaiah Chowdary Nannapaneni
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Abstract
The present invention relates to a process for the preparation of high pure Eribulin and Eribulin Mesylate. The present invention involves preparation of high pure Eribulin and its mesylate salt involving chiral acid addition salts of Eribulin.
Claims11
A process for the preparation of high purity Eribulin mesylate (formula II):
- comprising the steps of:
- a) reacting Eribulin free base with a protected chiral acid to form the corresponding acid addition salt of Eribulin,
- b) purifying the acid addition salt of Eribulin by recrystallization to control the related impurities,
- c) treating the salt with a base to liberate high purity Eribulin, and
- d) treating high purity Eribulin base with ammonium methanesulfonate to produce high purity Eribulin mesylate.
2 more elements
Dependencies are inferred from the claim text.