Back to results
US 12,522,587 B2Granted
Cancer treatments targeting cancer stem cells
AssigneeRemedy Plan, Inc.
InventorsGregory Thomas Crimmins, Dennise Alexandra De Jesús Diaz, Yushma Bhurruth-Alcor
Life of this patent
Estimating the term…
Abstract
Disclosed are compounds, methods, compositions, and kits that allow for treating cancer by, e.g., targeting cancer stem cells. In some embodiments, the cancer is colorectal cancer, gastric cancer, gastrointestinal stromal tumor, ovarian cancer, lung cancer, breast cancer, pancreatic cancer, prostate cancer, testicular cancer, or lymphoma. In some embodiments, the cancer is liver cancer, endometrial cancer, leukemia, or multiple myeloma. The compounds utilized in the disclosure are of Formula (0), (O′), and (I):
Claims25
A compound of Formula (I):
- or a pharmaceutically acceptable salt, solvate, hydrate, polymorph, co-crystal, tautomer, stereoisomer, isotopically labeled derivative, or prodrug thereof, wherein:
- each instance of Ra is independently hydrogen, substituted or unsubstituted C1-6 alkyl, an oxygen protecting group when attached to an oxygen atom, or a nitrogen protecting group when attached to a nitrogen atom;
- each instance of Y is independently N or CR4;
- each instance of R4 is independently hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, —ORa, —N(Ra)2, or —CN;
- is phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, imidazolyl, oxazolyl, azetidinyl, —C≡C—, or
- bond b and bond c are meta or para to each other when
- is phenyl, pyridinyl, pyridazinyl, pyrimidinyl, or pyrazinyl;
- each instance of R5 is independently hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, —ORa, —N(Ra)2, or —CN;
- n is 0, 1, 2, 3, or 4, as valency permits, wherein when n is 1, 2, 3, or 4, no instance of R5 is attached to a nitrogen atom;
- L2 is —C(═O)—;
- R6 is hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted, 3- to 13-membered, monocyclic or bicyclic carbocyclyl, substituted or unsubstituted, 3- to 13-membered, monocyclic or bicyclic heterocyclyl, substituted or unsubstituted, 6- to 11-membered, monocyclic or bicyclic aryl, substituted or unsubstituted, 5- to 11-membered, monocyclic or bicyclic heteroaryl, or a nitrogen protecting group;
- R7 is substituted or unsubstituted, 3- to 7-membered, monocyclic carbocyclyl, substituted or unsubstituted, 3- to 7-membered, monocyclic heterocyclyl, unsubstituted phenyl, substituted or unsubstituted pyridinyl, substituted or unsubstituted pyrimidinyl, substituted or unsubstituted pyridazinyl, substituted or unsubstituted triazinyl, unsubstituted pyrazolyl, substituted or unsubstituted imidazolyl, substituted or unsubstituted oxazolyl, substituted or unsubstituted thiazolyl, or unsubstituted furyl;
- and
- each instance of R8 is independently hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, —ORa, —N(Ra)2, or —CN.
11 more elements
Dependencies are inferred from the claim text.