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US 12,522,571 B2Granted
Compounds, devices, and uses thereof
AssigneeSigilon Therapeutics, Inc.
InventorsOmid Veiseh, Richard Heidebrecht, Paul Kevin Wotton, Matthias Alexander Oberli, Robert James Miller
Life of this patent
Estimating the term…
Abstract
The present invention provides compounds, e.g., compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are implantable elements (e.g., devices and materials) comprising the same, as well as methods of use thereof, e.g., for treating or preventing a disease, disorder, or condition.
Claims12
A compound of Formula (II-c):
- or a salt thereof, wherein:
- Ring M1 is phenyl optionally substituted with 1-4 R3;
- Z1 is C2-C12 heteroalkyl, cycloalkyl, heterocyclyl, or heteroaryl, each of which is optionally substituted by one or more R5;
- X is absent or O;
- each of R2a, R2b, R2c, and R2d is independently hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, halo, cyano, nitro, amino, cycloalkyl, heterocyclyl, aryl, or heteroaryl;
- or R2a and R2b or R2c and R2d are taken together to form an oxo group;
- RC and RD are independently hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein each of alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with 1-6 R6;
- or RC and RD, taken together with the nitrogen atom to which they are attached, form a ring, optionally substituted with 1-6 R6;
- each of R3, R5, and R6 is independently alkyl, alkenyl, alkynyl, heteroalkyl, halogen, cyano, azido, oxo, cycloalkyl, heterocyclyl, aryl, or heteroaryl;
- m is 0, 1, 2, 3, 4, 5, or 6;
- n is 1, 2, 3, 4, 5, or 6;
- wherein the triazolyl ring is
- and,
- wherein the compound is not
11 more elements
A pharmaceutical composition comprising a compound of Formula (II-c):
- or a salt thereof, wherein:
- Ring M1 is phenyl optionally substituted with 1-4 R3;
- Z1 is C2-C12heteroalkyl, cycloalkyl, heterocyclyl, or heteroaryl, each of which is optionally substituted by one or more R5;
- X is absent or O;
- each of R2a, R2b, R2c, and R2d is independently hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, halo, cyano, nitro, amino, cycloalkyl, heterocyclyl, aryl, or heteroaryl;
- or R2a and R2b or R2c and R2d are taken together to form an oxo group;
- RC and RD are independently hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein each of alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with 1-6 R6;
- or RC and RD, taken together with the nitrogen atom to which they are attached, form a ring, optionally substituted with 1-6 R6;
- each of R3, R5, and R6 is independently alkyl, alkenyl, alkynyl, heteroalkyl, halogen, cyano, azido, oxo, cycloalkyl, heterocyclyl, aryl, or heteroaryl;
- m is 0, 1, 2, 3, 4, 5, or 6;
- n is 1, 2, 3, 4, 5, or 6;
- the triazolyl ring is
- and,
- wherein the compound is not
- and a pharmaceutically acceptable excipient.
12 more elements
Dependencies are inferred from the claim text.